The 2021 congress of the International Neuromodulation Society, themed Neuromodulation: From Scientific Theory to Revolutionary Therapy, will emphasize the field’s transformative force on disease treatment. A strong theoretical framework has underpinned studies that offer insight into mechanisms of action, and the field has matured into proven therapies delivered with refined and personalized techniques. Plenary sessions from world experts, panel discussions, oral abstract presentations, poster sessions and networking opportunities convey knowledge from multiple disciplines about current practice, future developments, and solutions for neuromodulation therapy of the central, peripheral, and autonomic nervous system. The congress will bring together over 1,500 scientists, researchers, engineers, device developers and healthcare providers from around the globe to share evidence-based knowledge about basic, translational and clinical research; emerging technologies; and global health care trends in order to improve skills, outcomes, and access to patient care. We invite you to join us!